Chloride substituents modify the physical properties of organic compounds in several ways. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Formula: C6H6BClO2.
de Araujo, Rodrigo Santos Aquino;Carmo, Julianderson de Oliveira dos Santos;de Omena Silva, Simone Lara;Costa da Silva, Camila Radelley Azevedo;Souza, Tayhana Priscila Medeiros;Melo, Natalia Barbosa de;Bourguignon, Jean-Jacques;Schmitt, Martine;Aquino, Thiago Mendonca de;Rodarte, Renato Santos;Moura, Ricardo Olimpio de;Barbosa Filho, Jose Maria;Barreto, Emiliano;Mendonca-Junior, Francisco Jaime Bezerra research published 《 Coumarin Derivatives Exert Anti-Lung Cancer Activity by Inhibition of Epithelial-Mesenchymal Transition and Migration in A549 Cells》, the research content is summarized as follows. A series of coumarin derivatives and isosteres were synthesized from the reaction of triflic intermediates with phenylboronic acids, terminal alkynes, and organozinc compounds through palladium-catalyzed cross-coupling reactions. The in vitro cytotoxic effect of the compounds was evaluated against two non-small cell lung carcinoma (NSCLC) cell lines (A-549 and H2170) and a normal cell line (NIH-3T3) using cisplatin as a reference drug. Addnl., the effects of the most promising coumarin derivative (9f) in reversing the epithelial-to-mesenchymal transition (EMT) in IL-1β-stimulated A549 cells and in inhibiting the EMT-associated migratory ability in A549 cells were also evaluated. 9f had the greatest cytotoxic effect (CC50 = 7.1 ± 0.8 and 3.3 ± 0.5 μM, resp. against A549 and H2170 cells) and CC50 value of 25.8 μM for NIH-3T3 cells. 9f inhibited the IL-1β-induced EMT in epithelial cells by inhibiting the F-actin reorganization, attenuating changes in the actin cytoskeleton reorganization, and downregulating vimentin in A549 cells stimulated by IL-1β. Treatment of A549 cells with 9f at 7 μM for 24 h significantly reduced the migration of IL-1β-stimulated cells, which is a phenomenon confirmed by qual. assessment of the wound closure. Taken together, our findings suggest that coumarin derivatives, especially compound 9f, may become a promising candidate for lung cancer therapy, especially in lung cancer promoted by NSCLC cell lines.
Formula: C6H6BClO2, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics