Nap, Rikkert J.;Qiao, Baofu;Palmer, Liam C.;Stupp, Samuel I.;Olvera de la Cruz, Monica;Szleifer, Igal published 《Acid-base equilibrium and dielectric environment regulate charge in supramolecular nanofibers》. The research results were published in《Frontiers in Chemistry (Lausanne, Switzerland)》 in 2022.Application In Synthesis of Rubidiumchloride The article conveys some information:
Peptide amphiphiles are a class of mols. that can self-assemble into a variety of supramol. structures, including high-aspect-ratio nanofibers. It is challenging to model and predict the charges in these supramol. nanofibers because the ionization state of the peptides are not fixed but liable to change due to the acid-base equilibrium that is coupled to the structural organization of the peptide amphiphile mols. Here, we have developed a theor. model to describe and predict the amount of charge found on self-assembled peptide amphiphiles as a function of pH and ion concentration In particular, we computed the amount of charge of peptide amphiphiles nanofibers with the sequence C16 – V2A2E2. In our theor. formulation, we consider charge regulation of the carboxylic acid groups, which involves the acid-base chem. equilibrium of the glutamic acid residues and the possibility of ion condensation. The charge regulation is coupled with the local dielec. environment by allowing for a varying dielec. constant that also includes a position-dependent electrostatic solvation energy for the charged species. We find that the charges on the glutamic acid residues of the peptide amphiphile nanofiber are much lower than the same functional group in aqueous solution There is a strong coupling between the charging via the acid-base equilibrium and the local dielec. environment. Our model predicts a much lower degree of deprotonation for a position-dependent relative dielec. constant compared to a constant dielec. background. Furthermore, the shape and size of the electrostatic potential as well as the counterion distribution are quant. and qual. different. These results indicate that an accurate model of peptide amphiphile self-assembly must take into account charge regulation of acidic groups through acid-base equilibrium and ion condensation, as well as coupling to the local dielec. environment. The experimental procedure involved many compounds, such as Rubidiumchloride (cas: 7791-11-9) .
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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics