Month: September 2022

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Name: 3-Chlorophenylacetic acid.

To, Tuong A.;Nguyen, Chuc T.;Tran, My H. P.;Huynh, Thai Q.;Nguyen, Tung T.;Le, Nhan T. H.;Nguyen, Anh D.;Tran, Phong D.;Phan, Nam T. S. research published 《 A new pathway to pyrrolo[1,2-a]quinoxalines via solvent-free one-pot strategy utilizing FeMoSe nanosheets as efficient recyclable synergistic catalyst》, the research content is summarized as follows. FeMoSe nanocatalyst was synthesized using solvothermal approach from readily available precursors, namely Mo(CO)₆, FeSO₄ and Se, and characterized by spectroscopic and microscopic anal. The FeMoSe material offered high catalytic activity in the synthesis of pyrrolo[1,2-a]quinoxalines I [R = H, Me, OMe, etc.; Ar = Ph, 2-thiophenyl, 4-BrC₆H₄, etc.] via solvent-free one-pot strategy starting from 2-nitroanilines. The FeMoSe material offered high catalytic activity in the synthesis of pyrrolo[1,2-a]quinoxalines I via solvent-free one-pot strategy starting from 2-nitroanilines. The synthesis of pyrrolo[1,2-a]quinoxalines I using such a synergistic bimetallic system was not previously reported.

Name: 3-Chlorophenylacetic acid, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Safety of 2,3-Dichlorobenzaldehyde.

Shaheen, Mennatallah A.;El-Emam, Ali A.;El-Gohary, Nadia S. research published 《 Design, synthesis and biological evaluation of new series of hexahydroquinoline and fused quinoline derivatives as potent inhibitors of wild-type EGFR and mutant EGFR (L858R and T790M)》, the research content is summarized as follows. New series of hexahydroquinoline and fused quinoline derivatives were designed and synthesized. The thirty seven new compounds were screened for in vitro antitumor activity against HepG2, HCT-116 and MCF-7 cancer cells. Results indicated that certain compounds, including I, have the strongest potency against the three cancer cells, and they were further screened for in vitro cytotoxicity against A431 and H1975 cancer cells, as well as WI38 and WISH normal cells. Results revealed that I potently inhibited the growth of H1975 cells harboring EGFR^T790M mutation (IC₅₀ = 1.32 ± 0.2μM) over A431 cells overexpressing EGFR^WT (IC₅₀ = 4.96 ± 0.3μM). Moreover, the seven compounds displayed low cytotoxicity against the tested normal cells. The seven potent antitumor compounds were examined for their ability to inhibit the activity of EGFR^WT. The attained data manifested that I has remarkable EGFR^WT inhibitory activity (IC₅₀ = 0.083 ± 0.002μM) compared to erlotinib (IC₅₀ = 0.067 ± 0.002μM). Compound I was further studied for its enzymic inhibitory activity against other eight human kinases, and it displayed outstanding inhibitory activity against EGFR^L858R and EGFR^T790M mutants (IC₅₀ = 0.053 ± 0.002, 0.026 ± 0.001μM, resp.), as well as JAK3 (IC₅₀ = 0.069 ± 0.003μM). Anal. of cell cycle evidenced that I induces cell cycle arrest in G2/M and pre-G1 phases in the tested cancer cells. In addition, cancer cell death induced by I was proved to take place via apoptosis supported by elevated Bax/Bcl-2 ratio in the tested cancer cells. Moreover, docking results confirmed the good binding interactions of I with EGFR^WT, EGFR^L858R, EGFR^T790M and JAK3, which came in agreement with the results of in vitro enzyme assay. Further, I is predicted to have good oral absorption, good drug-likeness properties and low toxicity risks in human.

6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., Safety of 2,3-Dichlorobenzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Category: chlorides-buliding-blocks.

Korkmaz, Adem;Bursal, Ercan research published 《 Benzothiazole sulfonate derivatives bearing azomethine: Synthesis, characterization, enzyme inhibition and molecular docking study》, the research content is summarized as follows. Enzyme inhibition is one of the most applied ways to find new diagnostic facilities for the prevention and treatment of many health problems. For example, tyrosinase and pancreatic lipase inhibition have been used for the treatment of skin pigmentation problems and obesity, resp. This study mainly focused on evaluating inhibition of tyrosinase and pancreatic lipase by newly synthesized sulfonate derivatives I [R = 2,4,6-Me₃C₆H₂, 2-naphthyl, 4-BrC₆H₄, etc.]. The structural characterizations of the compounds were performed by ¹H NMR, ¹³C NMR and HR-MS analyses. According to the in-vitro enzyme inhibition methods, compound I [R = 4-FC₆H₄] had the highest tyrosinase inhibitory activity (46.9 ± 3.6μM IC₅₀ value). On the other hand, effective pancreatic lipase inhibitory activities of I [R = 4-MeOC₆H₄, 4-FC₆H₄, 4-MeC₆H₄] were determined from their low IC₅₀ values 58.3 ± 6.7μM, 59.5 ± 13.8μM and 64.8 ± 6.3μM, resp. Mol. docking studies were also conducted with tyrosinase and pancreatic lipase enzymes sep. Finally, the ADME studies were carried out to determine the pharmacokinetics, drug similarities and medicinal properties of the target compounds

Category: chlorides-buliding-blocks, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. SDS of cas: 6334-18-5.

Jiang, Ling;Lu, Qingqing;Tang, Qianqian;Cheng, Yue;Chu, Xiaohe research published 《 L-cysteine catalyzed one-pot synthesis of bicyclic δ-lactones under ball-milling conditions》, the research content is summarized as follows. A series of bicyclic δ-lactones were synthesized in moderate to good yields via a simple one-pot reaction. The facile method depended on one-pot three-component reaction of aromatic aldehydes, Meldrum’s acid and δ-diketones in the presence of L-cysteine as a catalyst under ball-milling conditions. The reactions were completed in mere 30 min in 50-87% yields. The synthesized compounds were characterized by ¹H NMR, ¹³C NMR and ESI-MS. Environmental acceptability, wide substrate scope, low cost and operational simplicity were the key features of this method.

6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., SDS of cas: 6334-18-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Computed Properties of 349-88-2.

Xie, Dandan;Hu, Xin;Ren, Xiaoli;Yang, Zaiping research published 《 Synthesis and bioactivities of novel piperonylic acid derivatives containing a sulfonic acid ester moiety》, the research content is summarized as follows. In order to develop efficient, broad-spectrum and structurally simple agricultural bactericide, the structure of piperonylic acid was modified and a series of novel piperonylic acid derivatives I [R = Ph, 2-naphthyl, benzyl, etc.] containing a sulfonic acid ester moiety was synthesized. Bioassay results indicated the compounds I exhibited significantly antibacterial activities. Among them, compound I [R = phenyl] exhibited excellent antibacterial activities against Pseudomonas syringae pv. Actinidiae (Psa), with inhibitory value 99 and 85% at 100μg/mL and 50μg/mL, resp., which was higher than that of thiodiazole-copper (84 and 77%) and bismerthiazol (96 and 78%). In addition, some compounds also showed moderate insecticidal activity against Spodoptera frugiperda. The above mentioned results confirm the broadening of the application of piperonylic acid, with reliable support for the development of novel agrochem. bactericide.

Computed Properties of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Electric Literature of 2905-24-0.

Xie, Dandan;Hu, Xin;Ren, Xiaoli;Yang, Zaiping research published 《 Synthesis and bioactivities of novel piperonylic acid derivatives containing a sulfonic acid ester moiety》, the research content is summarized as follows. In order to develop efficient, broad-spectrum and structurally simple agricultural bactericide, the structure of piperonylic acid was modified and a series of novel piperonylic acid derivatives I [R = Ph, 2-naphthyl, benzyl, etc.] containing a sulfonic acid ester moiety was synthesized. Bioassay results indicated the compounds I exhibited significantly antibacterial activities. Among them, compound I [R = phenyl] exhibited excellent antibacterial activities against Pseudomonas syringae pv. Actinidiae (Psa), with inhibitory value 99 and 85% at 100μg/mL and 50μg/mL, resp., which was higher than that of thiodiazole-copper (84 and 77%) and bismerthiazol (96 and 78%). In addition, some compounds also showed moderate insecticidal activity against Spodoptera frugiperda. The above mentioned results confirm the broadening of the application of piperonylic acid, with reliable support for the development of novel agrochem. bactericide.

Electric Literature of 2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., 2905-24-0.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Product Details of C8H7ClO2.

To, Tuong A.;Vo, Yen H.;Nguyen, Hue T. T.;Ha, Phuong T. M.;Doan, Son H.;Doan, Tan L. H.;Li, Shuang;Le, Ha V.;Tu, Thach N.;Phan, Nam T. S. research published 《 Iron-catalyzed one-pot sequential transformations:synthesis of quinazolinones via oxidative Csp³-H bond activation using a new metal-organic framework as catalyst》, the research content is summarized as follows. A new mixed-linker iron-based MOF VNU-21 [Fe₃(BTC)(EDB)₂·12.27H₂O] was synthesized via mixed-linker synthetic strategy using 1,3,5-benzenetricarboxylic acid, 4,4′-ethynylenedibenzoic acid and FeCl₂. The VNU-21 was consequently used as a recyclable heterogeneous catalyst in the one-pot synthesis of quinazolinones I [R = H, 2-Me, 4-Br, etc.; R¹ = H, 7-Me, 6-F, etc.] via two steps under oxygen atm. The synthetic scheme involved iron-catalyzed oxidative Csp³-H bond activation to achieve decarboxylation of phenylacetic acids and succeeding metal-free oxidative cyclization with 2-aminobenzamides. The VNU-21 was more effective than a series of heterogeneous and homogeneous catalysts. It was possible to reutilized the iron-based framework without a considerable deterioration in catalytic performance.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Product Details of C8H7ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Reference of 6334-18-5.

Shaheen, Mennatallah A.;El-Emam, Ali A.;El-Gohary, Nadia S. research published 《 1,4,5,6,7,8-Hexahydroquinolines and 5,6,7,8-tetrahydronaphthalenes: A new class of antitumor agents targeting the colchicine binding site of tubulin》, the research content is summarized as follows. New series of 2-amino-1,4,5,6,7,8-hexahydroquinoline-3-carbonitriles I (R = 2,3-dichlorophenyl, 2,4-difluorophenyl) and 2-amino-5,6,7,8-tetrahydronaphthalene-1,3-dicarbonitriles II (R¹ = 2,6-difluorophenyl, [1,3]benzodioxol-4-yl, anthracen-9-yl, etc.) were synthesized and evaluated for their antitumor activity. In vitro antitumor screening of the new members against HepG2, HCT-116 and MCF-7 cancer cells showed that the tetrahydronaphthalene-1,3-dicarbonitrile II (R¹ = 2-chloro-6-fluorophenyl) (A) has the highest potency against the three tested cancer cells (IC₅₀ = 6.02, 8.45 and 6.28μM, resp.). In addition, compound A displayed low cytotoxicity against WI38 and WISH normal cells (IC₅₀ = 51.78 and 42.36μM, resp.), and it might be utilized as a potent and selective antitumor agent. Compound A was further studied for its effect on tubulin polymerization, different phases of cell cycle, apoptosis and caspases 3/9 levels. Results revealed that analog compound A has good tubulin polymerization inhibitory activity (IC₅₀ = 3.64μM). Addnl., it induced significant accumulation of the tested cancer cells in G2/M phase, and induced cell death primarily via apoptosis. Besides, it showed evident increase in caspase-3 level in HepG2 and HCT-116 cells, and caspase-9 level in MCF-7 cells. Further, docking studies proved the exact fit of compound A into the colchicine binding site of tubulin.

6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., Reference of 6334-18-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics