Month: September 2022

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Category: chlorides-buliding-blocks.

Korkmaz, Adem;Bursal, Ercan research published 《 An in vitro and in silico study on the synthesis and characterization of novel bis(sulfonate) derivatives as tyrosinase and pancreatic lipase inhibitors》, the research content is summarized as follows. Herein, authors present a straightforward synthetic strategy mediated by triethylamine to prepare the target salicylaldehyde functional group’s bearing bis(sulfonate) derivatives The novel bis(sulfonate) derivatives were designed, synthesized, and characterized for the first time. Enzyme inhibition effects and enzyme interactions of compounds were evaluated on tyrosinase and pancreatic lipase enzymes by using in silico and in vitro methods. According to the enzyme assays, compound I had more effective inhibition against the pancreatic lipase enzyme with a lower IC₅₀ value (53.3 ± 2.7μM) than the other compounds On the other hand, two of the newly synthesized compounds (II and I) had effective inhibitions against the tyrosinase enzyme with having (49.5 ± 2.5μM) IC₅₀ values. In addition, mol. docking studies were performed to determine the interactions and binding energy levels of the bis(sulfonate) derivatives with tyrosinase and pancreatic lipase. Also, addnl. ADME studies of the bis(sulfonate) compounds were evaluated.

Category: chlorides-buliding-blocks, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Safety of 2,3-Dichlorobenzaldehyde.

Jiang, Ling;Lu, Qingqing;Dong, Jingwen;Chu, Xiaohe research published 《 Mechano-biocatalytic rapid synthesis of 2-amino-3-cyano-4H-pyran derivatives》, the research content is summarized as follows. A series of 2-amino-3-cyano-4H-pyrans I (R¹ = Ph, 2-FC₆H₄, 3-MeOC₆H₄, etc.) and II were synthesized in good to excellent yields via a simple one-pot reaction. The facile method depended on one-pot three-component reaction of aromatic aldehyde, malononitrile and dimedone or 3-(dimethylamino)phenol in the presence of bovine serum albumin (BSA) as the catalyst under ball-milling conditions. The reactions were completed in 40 min in 80-98% yields.

Safety of 2,3-Dichlorobenzaldehyde, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics