Brik, Ashraf; Wu, Chung-Yi; Best, Michael D.; Wong, Chi-Huey published the artcile< Tetrabutylammonium fluoride-assisted rapid N9-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ>, Safety of 2,6-Dichloro-9-methyl-9H-purine, the main research area is combinatorial synthesis alkylated purine preparation; alkylation tetrabutylammonium fluoride assisted purine preparation; sulfotransferase inhibition alkylated purine.
Tremendous efforts have been invested in the synthesis of purine libraries due to their importance in targeting various enzymes involved in different diseases and cellular processes. T The synthesis of N9-alkylated purine scaffolds relied mostly on Mitsunobu conditions with a variety of alcs. or strong basic conditions with different organic halides. A more reliable and efficient way for the synthesis of N9-alkylated purine scaffolds is reported. This method uses tetrabutylammonium fluoride (TBAF) to assist such chem. In many cases, the reactions were completed within 10 min and gave the desired product in high yield and selectivity. Moreover, these mild reaction conditions permitted its use in combinatorial reactions in microtiter plates followed by in situ screening for the discovery of potent sulfotransferase inhibitors.
Bioorganic & Medicinal Chemistry published new progress about Alkylation. 2382-10-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H4Cl2N4, Safety of 2,6-Dichloro-9-methyl-9H-purine.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics