Cao, Ren-Fei; Yu, Lu; Huo, Yu-Xuan; Li, Yao; Xue, Xiao-Song; Chen, Zhi-Min published the artcile< Chiral Lewis Base Catalyzed Enantioselective Selenocyclization of 1,1-Disubstituted Alkenes: Asymmetric Synthesis of Selenium-Containing 4H-3,1-Benzoxazines>, SDS of cas: 128-09-6, the main research area is alkene aryl selenylsuccinimide diphenylphosphinoamino binaphthyl catalyst enantioselective selenocyclization; aryl selenyl benzoxazine preparation.
An enantioselective selenocyclization of 1,1-disubstituted alkenes was achieved for the first time, which was enabled by a novel combination of a chiral BINAM-derived sulfide and an achiral Lewis acid. Various selenium-containing 4H-3,1-benzoxazines, which were widely present in a range of medicinally relevant mols., were readily obtained in moderate to good yields and good to excellent enantioselectivities. A series of tetrasubstituted carbon stereocenters were facilely constructed.
Organic Letters published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, SDS of cas: 128-09-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics