Carroll, William A.; Kalvin, Douglas M.; Perez Medrano, Arturo; Florjancic, Alan S.; Wang, Ying; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Grayson, George; Honore, Prisca; Jarvis, Michael F. published the artcile< Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists>, Formula: C8H6Cl2O2, the main research area is purinoceptor antagonist analgesic triazole preparation SAR.
Structure-activity relationship (SAR) studies were conducted around early tetrazole-based leads 3 and 4. Replacements for the tetrazole core were investigated and the pendant benzyl substitution was reoptimized with a triazole isostere. Triazole-based P2X7 antagonists were identified with similar potency to the lead compound 4 but with improved physiochem. properties. Compound 12 (I) was active in a rat model of neuropathic pain.
Bioorganic & Medicinal Chemistry Letters published new progress about Analgesics. 2905-54-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6Cl2O2, Formula: C8H6Cl2O2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics