Zhang, Kun;Rombach, David;Notel, Nicolas Yannick;Jeschke, Gunnar;Katayev, Dmitry published 《Radical Trifluoroacetylation of Alkenes Triggered by a Visible-Light-Promoted C-O Bond Fragmentation of Trifluoroacetic Anhydride》 in 2021. The article was appeared in 《Angewandte Chemie, International Edition》. They have made some progress in their research.Formula: C10H13ClO3 The article mentions the following:
A mild and operationally simple trifluoroacylation strategy of olefines was reported, that utilized trifluoroacetic anhydride as a low-cost and readily available reagent. This light-mediated process was fundamentally different from conventional methodologies and occurs through a trifluoroacyl radical mechanism promoted by a photocatalyst, which triggers a C-O bond fragmentation. Mechanistic studies (kinetic isotope effects, spectroelectrochem., optical spectroscopy, theor. investigations) highlighted the evidence of a fleeting CF3CO radical under photoredox conditions. The trifluoroacyl radical could be stabilized under CO atm., delivering the trifluoroacetylation product with higher chem. efficiency. Furthermore, the method could be turned into a trifluoromethylation protocol by simply changing the reaction parameters. Beyond simple alkenes, this method allows for chemo- and regioselective functionalization of small-mol. drugs and common pharmacophores. And (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) was used in the research process.
(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Formula: C10H13ClO3) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics