Dana, Srikanta; Valissery, Praveesh; Kumar, Sharvan; Gurung, Sumiran Kumar; Mondal, Neelima; Dhar, Suman Kumar; Mukhopadhyay, Pritam published the artcile< Synthesis of Novel Ciprofloxacin-Based Hybrid Molecules toward Potent Antimalarial Activity>, Related Products of 17082-09-6, the main research area is chloroquinolone ciprofloxacin hybrid pharmacophore antimalarial.
Antimalarial drug resistance is a serious obstacle in the persistent quest to eradicate malaria. There is a need for potent chem. agents that are able to act on drug-resistant Plasmodium falciparum populations at reasonable concentrations without any related toxicity to the host. By rational drug design, we envisaged to address this issue by generating a novel hybrid drug possessing two pharmacophores that can act on two unique and independent targets within the cell. We synthesized a new class of ciprofloxacin-based hybrid mols., which have been integrated with acridine, quinolone, sulfonamide, and cinnamoyl pharmacophores. We realized a potent chloroquinolone-ciprofloxacin-based antimalarial hybrid (CQ-CFX) whose mechanism of action is unlike that of its parent mols. indicating a unique biol. target. CQ-CFX is not only potent against CQ-resistant and susceptible strains of Plasmodium falciparum at low nanomolar concentrations (IC50 values are 63.17 ± 1.2 nM and 25.52 ± 4.45 nM, resp.) but is also not toxic to mammalian and bacterial systems up to 20μM and 1μM, resp.
ACS Medicinal Chemistry Letters published new progress about Antimalarials. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Related Products of 17082-09-6.
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Chlorides – an overview | ScienceDirect Topics