Gilfillan, Lynne; Blair, Adele; Morris, Brian J.; Pratt, Judith A.; Schweiger, Lutz; Pimlott, Sally; Sutherland, Andrew published the artcile< Synthesis and biological evaluation of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones; potential imaging agents of the metabotropic glutamate 2 receptor>, Recommanded Product: 5-Chloro-2-nitro-4-(trifluoromethyl)aniline, the main research area is dihydrobenzodiazepinone preparation PET SPECT imaging agent.
A focused library of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones containing sites for 11C-, 18F- and 123I-labeling were prepared and evaluated against membrane expressing human recombinant metabotropic glutamate 2 receptor (mGluR2). The compounds are non-competitive antagonists with nanomolar affinity. HPLC evaluation of the physiochem. properties of these compounds identified two candidates for PET and SPECT imaging of mGluR2.
MedChemComm published new progress about Combinatorial library. 35375-74-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3N2O2, Recommanded Product: 5-Chloro-2-nitro-4-(trifluoromethyl)aniline.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics