Igarashi, Susumu; Inami, Hiroshi; Hara, Hiromu; Koutoku, Hiroshi; Oritani, Hiroyuki; Mase, Toshiyasu published the artcile< A novel class of inhibitors for human and rat steroid 5α-reductases: synthesis and biological evaluation of indoline and aniline derivatives>, Name: Methyl 3-chloro-4-hydroxybenzoate, the main research area is steroid reductase inhibitor carboxyphenoxyindoline carboxyphenoxyaniline preparation.
Searching for novel nonsteroidal inhibitors of human and rat prostatic 5α-reductases led to a new series of indoline and aniline derivatives that showed potent inhibitory activities for both enzymes. Among them, 3-chloro-4-{[1-(4-phenoxybenzyl)indolin-5-yl]oxy}benzoic acid (YM-36117) showed a more potent inhibitory activity for the human enzyme than ONO-3805 with an IC50 value of 5.3 nM and a reduced rat prostatic dihydrotestosterone (DHT) concentration by oral administration. The synthesis and the structure-activity relationships of these indoline and aniline derivatives are presented.
Chemical & Pharmaceutical Bulletin published new progress about 3964-57-6. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Name: Methyl 3-chloro-4-hydroxybenzoate.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics