Joseph, Alex; Pai, Aravinda; Srinivasan, K. K.; Kedar, Tukaram; Thomas, Angel Treasa; Jessy, E. M.; Singla, Rajeev K. published the artcile< Synthesis and anticancer activity of some novel 3-(1,3,4-thiadiazol-2-yl)-quinazolin-4(3H)-ones>, Synthetic Route of 70057-67-9, the main research area is thiadiazolylquinazolinone preparation anticancer; quinazolinone thiadiazolyl preparation anticancer.
The synthesis of various thiadiazole-substituted quinazolin-4(3H)-ones was reported. Novel 3-(1,3,4-thiadiazol-2-yl)quinazolin-4(3H)-ones were synthesized by reaction of 5-alkyl/aryl-1,3,4-thiadiazol-2-amines with 2-methyl/phenyl-4H-1,3-benzoxazin-4-ones in the presence of pyridine. All the synthesized compounds were characterized by spectra and phys. data. In vitro anticancer activity of all the synthesized compounds was determined by MTT assay on HeLa cells. Most active compounds from in vitro studies were further evaluated for in vivo activity on Liquid tumor (Ehrlich’s Ascites Carcinoma; EAC)-induced mice. The anticancer activity of one of the compounds was comparable to that of cisplatin against HeLa cells, and this compound was also effective in preventing the growth of tumor in mice as indicated by decrease in progressive gain in body weight as well as increase in life span.
Orbital: The Electronic Journal of Chemistry published new progress about Antitumor agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Synthetic Route of 70057-67-9.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics