Kerru, Nagaraju; Gummidi, Lalitha; Bhaskaruni, Sandeep V. H. S.; Maddila, Surya Narayana; Jonnalagadda, Sreekantha B. published the artcile< Ultrasound-assisted synthesis and antibacterial activity of novel 1,3,4-thiadiazole-1H-pyrazol-4-yl-thiazolidin-4-one derivatives>, Related Products of 70057-67-9, the main research area is diphenylpyrazolyl phenylthiadiazolyl thiazolidinone preparation ultrasonication green chem antibacterial SAR.
An efficient multicomponent method was reported for the synthesis of biol. active 1,3,4-thiadiazole-1H-pyrazol-4-yl-thiazolidin-4-one hybrids I [R = H, 3-Cl, 3,4,5-tri-MeO, etc.] from the reaction of pyrazole-4-carbaldehyde, 5-(substituted phenyl)-1,3,4-thiadiazol-2-amines and 2-mercaptoacetic acid in ethanol under ultrasound irradiation Reactions gave excellent yields (91-97%) of desired products in short times (55-65 min) at 50°C. All the twelve new thiazolidin-4-one derivatives I were fully characterized by spectroscopic techniques and were screened for their antibacterial activity. Among the screened hybrids, derivatives I [R = 3-O2N, 4-O2N] showed fourfold (MBC = 156.3μg/cm3) and twofold (MBC = 312.5μg/cm3) stronger potency against Pseudomonas aeruginosa strain as compared to the standard ciprofloxacin. SAR studies revealed the importance of the functional groups on the Ph ring of 1,3,4-thiadiazol-2-amine moiety for varying bacterial activity. The electron-withdrawing (NO2) group at para- and meta-position played a significant role in enhancing the antibacterial activity. The prominent features of the described protocol are excellent yields, green protocol, catalyst-free, high atom economy (94%) and excellent carbon efficiency (98%).
Monatshefte fuer Chemie published new progress about Antibacterial agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Related Products of 70057-67-9.
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