Koo, Hyungmo; Kim, Hun Young; Oh, Kyungsoo published the artcile< (E)-Selective Friedel-Crafts acylation of alkynes to β-chlorovinyl ketones: Defying isomerizations in batch reactions by flow chemistry approaches>, Related Products of 17082-09-6, the main research area is beta chlorovinyl ketone diastereoselective preparation; alkyne acyl chloride Friedel Crafts acylation trichloroaluminum promoted flow.
The Friedel-Crafts acylation of alkynes stereoselectively provides (Z)-β-chlorovinyl ketones, whereas the AlCl3-promoted reaction yields a mixture of stereoisomeric β-chlorovinyl ketones. To develop the (E)-selective synthesis of β-chlorovinyl ketones (E)-RC(Cl):C(R2)COR1 [R = n-pentyl, c-hexyl, (CH2)2Ph, etc., R1 = cyclopropyl, Ph, 2-thienyl, etc., R2 = H, n-propyl], a flow chem. approach was devised for the Friedel-Crafts acylation of alkynes with acyl chlorides that defied the facile (E) → (Z) isomerization under AlCl3-promoted reaction conditions. Compared to batch reactions, the flow chem. approach provided a fast, clean, high yielding and stereoselective synthetic route to (E)-β-chlorovinyl ketones.
Organic Chemistry Frontiers published new progress about Acid halides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Related Products of 17082-09-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics