Kos, Nico J.; Van der Plas, Henk C. published the artcile< Deamination of 6-amino- and 6-(alkylamino)-9-alkylpurines and demethylation of methylthiopurines by sodium in liquid ammonia>, Electric Literature of 2382-10-7, the main research area is deamination aminopurine alkylaminopurine; demethylation methylthiopurine; mercaptopurine; purine amino deamination.
Treating 6-aminopurines, e.g. I (R = NH2; R1 = H, Cl, MeO) or 6-(alkylamino)purines, e.g. I (R = MeNH, NMe2, R1 = H) with Na in NH3(l) gave deaminated products I (R = H) via 1,6-dihydropurine intermediates II. Na in NH3(l) was also used to demethylate 6- and 8-(methylthio)purines, e.g., III (R2 = MeS) to give thiols, e.g. III (R2 = SH).
Journal of Organic Chemistry published new progress about Deamination. 2382-10-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H4Cl2N4, Electric Literature of 2382-10-7.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics