Makwane, Sunil; Srivastava, S. D.; Dua, Rajiv; Srivastava, S. K. published the artcile< Synthesis of 10-(2-phenyl-imidazo [2, 1-b] [1,3,4]thiadiazol-6-yl)-10H-phenothiazine derivatives and their in-vitro biological studies>, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is phenyl dihydroimidazothiadiazolyl phenothiazine preparation antifungal antibacterial activity SAR.
New series of 10-(2-phenyl-5,6-dihydro-imidazo[2,1-b][1,3,4]thiadiazole-6-yl)-10H-phenothiazine were synthesized by cyclization of various carboxylic acid with thiosemicarbazide in presence of sulfuric acid was to get aminothiadiazoles. Another way phenothiazine treated with chloroacetyl chloride yielded chloroacetyl phenothiazine . Further, cyclization of aminothiadiazoles and chloroacetyl phenothiazine followed by refluxation about 18 h to get the final products 10-(2-phenyl-5,6-dihydro-imidazo[2,1-b][1,3,4]thiadiazole-6-yl)-10H-phenothiazines. The structures of compounds were confirmed by IR, 1H-NMR, 13C NMR and mass spectroscopy and by chem. anal. All the above compounds were screened for their antimicrobial activity against some selected bacteria and fungi such as E. coli, B. subtilis, and S. typhi bacteria and A.niger, A. flavus and F. oxisporium fungi.
Journal of Applicable Chemistry (Lumami, India) published new progress about Antibacterial agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics