Matveevskaya, Vladislava V’s team published research in Inorganica Chimica Acta in 2022-05-24 | 67421-02-7

Inorganica Chimica Acta published new progress about Antitumor agents (mammary gland). 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Synthetic Route of 67421-02-7.

Matveevskaya, Vladislava V.; Pavlov, Dmitry I.; Samsonenko, Denis G.; Bonfili, Laura; Cuccioloni, Massimiliano; Benassi, Enrico; Pettinari, Riccardo; Potapov, Andrei S. published the artcile< Arene-ruthenium(II) complexes with tetracyclic oxime derivatives: synthesis, structure and antiproliferative activity against human breast cancer cells>, Synthetic Route of 67421-02-7, the main research area is ruthenium arene indenoquinoxalinone indenopyridopyrazinone tryptanthrin oxime complex preparation antitumor; crystal structure ruthenium arene indenoquinoxalinone indenopyridopyrazinone tryptanthrin oxime complex.

Six new arene-ruthenium(II) complexes containing two different η6-arene ligands – benzene and hexamethylbenzene, with indenoquinoxalinone oxime analogs (11H-indeno[1,2-b]quinoxalin-11-one oxime, 6H-indeno[1,2-b]pyrido[3,2-e]pyrazin-6-one oxime and 6-(hydroxyimino)indolo[2,1-b]quinazolin-12(6H)-one oxime (tryptanthrin-6-oxime)) as N,N’- chelating ligands are reported. The complexes were characterized by elemental anal., IR, UV-VIS, 1H and 13C NMR spectroscopy and by single-crystal X-ray structure anal. Complexes adopt a half-sandwich <> geometry with oxime ligands in anionic form, the ruthenium(II) center coordinates one arene, one N,N-bidentate oximate and one chloride ligand. The computational anal. of non-covalent intermol. interactions revealed weak attraction between the oxime oxygen atoms and the nearest hydrogen atoms of the oxime and the arene ligands. The cytotoxic activity of the complexes was evaluated against human breast cancer cell line MCF-7 and cisplatin-resistant human breast cancer cell line MCF-7CR as well as non-cancerous human breast epithelial cell line MCF10A. The cytotoxicity tests show micromolar IC50 values and tryptanthrin-6-oxime hexamethylbenzene-ruthenium(II) complex was found to exhibit the best antiproliferative activity among the studied compounds against the MCF-7 and MCF-7CR cell lines (IC50 9.0 ± 4.4 and 8.9 ± 1.5μM, resp.).

Inorganica Chimica Acta published new progress about Antitumor agents (mammary gland). 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Synthetic Route of 67421-02-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics