McClure, Kelly J.; Maher, Michael; Wu, Nancy; Chaplan, Sandra R.; Eckert, William A. III; Lee, Dong H.; Wickenden, Alan D.; Hermann, Michelle; Allison, Brett; Hawryluk, Natalie; Breitenbucher, J. Guy; Grice, Cheryl A. published the artcile< Discovery of a novel series of selective HCN1 blockers>, COA of Formula: C8H4ClF3O2, the main research area is HCN1 blocker preparation SAR; heterocyclylindanemethyl heterocyclylethyl benzamide preparation; structure heterocyclylindanemethyl heterocyclylethyl benzamide inhibition HCN1 cation channel.
The discovery of a series of novel, potent, and selective blockers of the hyperpolarization-activated cation-nonselective cyclic nucleotide-modulated ion channel HCN1 is disclosed. Here we report an SAR study around a series of selective blockers of the HCN1 channel. Utilization of a high-throughput VIPR assay led to the identification of a novel series of 2,2-disubstituted indane derivatives, which had moderate selectivity and potency at HCN1. Optimization of this hit led to the identification of the potent, 1,1-disubstituted cyclohexane HCN1 blocker, 2-ethoxy-N-((1-(4-isopropylpiperazin-1-yl)cyclohexyl)methyl)benzamide. The work leading to the discovery of this compound is described herein.
Bioorganic & Medicinal Chemistry Letters published new progress about Analgesics. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, COA of Formula: C8H4ClF3O2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics