Raju, D. Suryanarayana; Sasidhar, R. L. C.; Vidyadhara, S. published the artcile< Synthesis and characterization of some novel 5-chloro benzimidazole-2-one derivatives with specific docking studies against PPAR-γ>, HPLC of Formula: 611-19-8, the main research area is piperidinyl benzimidazolone preparation mol docking; peroxisome proliferator activated receptor gamma; benzyl halide acyl chloride alkylation acylation.
A series of 5-chloro-1-(piperidin-4-yl)-1H-benzo[d]imidazole-2(3H)-one derivatives I (Ar = Ph, 4-ClC6H4, 4-BrC6H4, etc.) and II have been synthesized. The compounds were docked against peroxisome proliferator activated receptor-γ (PPAR-γ) by using MCULE software. It was found that the synthesized mols. were active against PPAR-γ by their comparative docking scores with that of standard marketed drugs i.e. Rosiglitazone and Pioglitazone. In particular compounds II (Ar = 2-MeC6H4) and I (Ar = 2-MeC6H4, 4-MeC6H4) showed more binding capacity. The synthesized mols. were identified to have good binding capacity with PPAR- γ according to their docking data.
International Journal of Life Science and Pharma Research published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, HPLC of Formula: 611-19-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics