Robbins, Daniel W.; Hartwig, John F. published the artcile< A C-H Borylation Approach to Suzuki-Miyaura Coupling of Typically Unstable 2-Heteroaryl and Polyfluorophenyl Boronates>, Recommanded Product: 1-Chloro-3,5-difluorobenzene, the main research area is borylation Suzuki Miyaura coupling iridium palladium catalyst; heteroaryl polyfluorophenyl boronate preparation Suzuki Miyaura coupling.
A method for the synthesis of biaryls and heterobiaryls from arenes and haloarenes without the intermediacy of unstable boronic acids is described. Pinacol boronate esters that are analogous to unstable boronic acids are formed in high yield by iridium-catalyzed C-H borylation of heteroarenes and fluoroarenes. These boronates are stable in the solid state or in solution and can be generated and used in situ. They couple with aryl halides in the presence of simple palladium catalysts, providing a convenient route to biaryl and heteroaryl products that have been challenging to prepare via boronic acids.
Organic Letters published new progress about Aromatic hydrocarbons Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Recommanded Product: 1-Chloro-3,5-difluorobenzene.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics