Song, Xin-Jian; Wang, Xu-Mei; Qi, Sun; Huang, Sheng-Tian; Yan, Wang published the artcile< Synthesis, crystal structure and antitumor activity of N-(5-aryl-1,3,4-thiadiazol-2-yl)-N'-((E)-styryl)ureas>, Name: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is aryl thiadiazolyl styryl urea preparation antitumor activity.
A series of N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N’-((E)-styryl)ureas I (R = 2-F, 3-Me, 4-Cl, etc.) was designed and synthesized as antitumor agents. The single crystal of compound I (R = 2-F) was also determined by X-ray crystallog. Crystal data: monoclinic, space group P21/n, a = 4.9401(8), b = 8.7100(15), c = 36.604(6) Å, β = 93.320(3)°, V = 1572.4(5) Å3, Z = 4, F(000) = 704, Dc = 1.438 g/cm3, μ = 0.228 mm-1, R = 0.0600 and wR = 0.1448 for 2743 independent reflections (Rint = 0.0418) and 2174 observed ones (I > 2σ(I)) were provided. The in vitro antitumor activities of compounds I were preliminarily evaluated by the standard MTT assay.
Chinese Journal of Structural Chemistry published new progress about Antitumor agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Name: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics