Su, Jinling; Zhang, Yan; Chen, Mingren; Li, Weiming; Qin, Xuewei; Xie, Yanping; Qin, Lixiao; Huang, Shihua; Zhang, Min published the artcile< A Copper Halide Promoted Regioselective Halogenation of Coumarins Using N-Halosuccinimides as Halide Source>, Application In Synthesis of 128-09-6, the main research area is chloro bromo coumarin preparation regioselective; coumarin halogenation halosuccinimide copper halide catalyst.
A safe, convenient, and regioselective synthesis of 3-halo coumarins using a metal halide (CuX2 alone or with ZnX2) promoted halogenation with N-halosuccinimides (NXS) as halide source. The synthesis involved the steady in situ generation of highly reactive pos. halogen (X+) by the coordination of copper or zinc with the N-halosuccinimide and subsequent electrophilic aromatic substitution of the electron-deficient coumarins. This procedure works well also for the halogenation of less electron-rich naphthoquinones, flavones, and methoxypsoralen in moderate to quant. yields. This protocol features simple exptl. conditions using readily available inexpensive reagents and provides a convenient approach to the chlorination or bromination of some useful heteroaromatic compounds
Synlett published new progress about Bromination catalysts (regioselective). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Application In Synthesis of 128-09-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics