Wan, Zehong; Boehm, Jeffrey C.; Bower, Michael J.; Kassis, Shouki; Lee, John C.; Zhao, Baoguang; Adams, Jerry L. published the artcile< N-Phenyl-N-purin-6-yl ureas: The design and synthesis of p38α MAP kinase inhibitors>, Safety of 2,6-Dichloro-9-methyl-9H-purine, the main research area is trisubstituted phenyl purine inhibitor p38 kinase preparation; crystal structure purine inhibitor p38 kinase.
The design, synthesis and SAR of a series of 2,6,9-trisubstituted purine inhibitors of p38α kinase is reported. Synthetic routes were devised to allow for array synthesis in which all three points of diversity could be facilely explored. The binding of this novel series to p38α kinase, which was predicted to have several key interactions in common with SB-203580, was confirmed by x-ray crystallog. of I (p38 IC50=82 nM).
Bioorganic & Medicinal Chemistry Letters published new progress about Crystal structure. 2382-10-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H4Cl2N4, Safety of 2,6-Dichloro-9-methyl-9H-purine.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics