Wang, Dong-Chao; Wu, Pan-Pan; Du, Pei-Yu; Qu, Gui-Rong; Guo, Hai-Ming published the artcile< Highly Diastereoselective Synthesis of Oxindoles Containing Vicinal Quaternary and Tertiary Stereocenters by a Domino Heck/Decarboxylative Alkynylation Sequence>, Recommanded Product: 3-(4-Chlorophenyl)propiolic acid, the main research area is phenylacrylamide phenylpropiolic acid palladium catalyst Heck decarboxylative alkynylation; oxindole diastereoselective preparation; pyrimidinecarboxamide phenylpropiolic acid palladium catalyst Heck decarboxylative alkynylation; pyrimidinyl spirooxindole diastereoselective preparation.
A palladium-catalyzed domino Heck/decarboxylative alkynylation reaction of trisubstituted alkenes or enamines was reported. For two different types of substrates, the current domino reaction employing different solvents and bases led to 3,3-disubstituted oxindoles and hydropyrimidinyl spirooxindoles containing vicinal quaternary and tertiary stereocenters in moderate to good yields, resp. The general applicability of this method was shown by gram-scale syntheses and diverse transformations of the reaction products. The enantioselective version for this domino process was also studied.
Organic Letters published new progress about Acrylamides Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Recommanded Product: 3-(4-Chlorophenyl)propiolic acid.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics