Willems, Maxime; Stevens, An-Sofie; Adriaens, Els; Plusquin, Michelle; Smeets, Karen; Van Goethem, Freddy; Vanparys, Philippe; Janssen, Colin; Remon, Jean-Paul published the artcile< An Adult Stem Cell Proliferation Assay in the Flatworm Model Macrostomum lignano to Predict the Carcinogenicity of Compounds>, Formula: C7H17Cl2N2O3P, the main research area is Macrostomum stem cell proliferation chem carcinogenicity prediction model.
Flatworms possess adult pluripotent stem cells whose dynamics can easily be exptl. assessed in vivo. This feature provides the unique opportunity to be used in a pharmacol. context to test the safety of chems. The objective of this study was to develop and assess the applicability of an alternative in vivo test with a low-level organism where stem cell proliferation is used as an endpoint to predict the carcinogenicity of chems. As a start, to obtain proof of concept with this new test model, we tested 4 known carcinogens (2 DNA-reactive and 2 non-DNA-reactive) and 2 noncarcinogens as neg. controls. We evaluated our carcinogenicity prediction model and advocate for its future use in pharmacol. safety screenings.
Applied In Vitro Toxicology published new progress about Adult, nonmammalian. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Formula: C7H17Cl2N2O3P.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics