Yamaguchi, Miyuki; Katsumata, Haruka; Manabe, Kei published the artcile< One-Pot Synthesis of Substituted Benzo[b]furans from Mono- and Dichlorophenols Using Palladium Catalysts Bearing Dihydroxyterphenylphosphine>, Application of C8H7ClO3, the main research area is Sonogashira Suzuki Miyaura coupling chlorophenol alkyne boronic acid; palladium dihydroxyterphenylphosphine XPhos catalyst benzofuran preparation.
A dihydroxyterphenylphosphine bearing cyclohexyl groups on the phosphorus atom (I, Cy-DHTP) was found to be a powerful ligand for the palladium-catalyzed one-pot synthesis of substituted benzo[b]furans from 2-chlorophenols and terminal alkynes. E.g., in presence of PdCl2(MeCN)2, I, and LiOCMe3, Sonogashira cross-coupling of 2-chlorophenol and PhCH2CH2CCH gave 82% benzo[b]furan derivative (II). This catalyst system was also applicable to the sequential one-pot synthesis of disubstituted benzo[b]furans from dichlorophenols via the Suzuki-Miyaura cross-coupling of chlorobenzo[b]furan with boronic acids. The use of two ligands, I and XPhos, is the key to promoting the reactions. Mechanistic studies suggest that the Pd-Cy-DHTP catalyst is the active species in the Sonogashira cross-coupling step, while the Pd-XPhos catalyst accelerates the Suzuki-Miyaura cross-coupling step.
Journal of Organic Chemistry published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Application of C8H7ClO3.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics