Yang, Yongjie; Huang, Liangbin; Jiang, Kai; Cao, Xiaohui; Yin, Biaolin published the artcile< LiCl-Mediated and Palladium-Catalyzed Oxidative Cyclization of Furan-Ynes via Dearomatizing Alkoxyalkenylation of Furan>, Name: 3-(4-Chlorophenyl)propiolic acid, the main research area is furylmethylalkynamide alc palladium catalyst regioselective diastereoselective chemoselective spirocyclization; oxaazaspirononenone preparation.
A LiCl-mediated and palladium(II)-catalyzed oxidative cyclization of furan-ynes via dearomatizing alkoxyalkenylation of furan was reported to afford polyfunctionalized spiro-dihydrofurans with diastereospecification and high Z/E selectivity. This protocol was likely to involved chloropalladation of alkynes, subsequent intramol. dearomatizing alkenylation of furan and final O-allylation. The d. functional theory (DFT) calculations demonstrated that the coordination of furan with dissolved Li+ weakens its nucleophilicity and promoted the Heck insertion and dissolved Cl- promoted chloropalladation of alkynes.
Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Name: 3-(4-Chlorophenyl)propiolic acid.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics