Yu, Yuye published the artcile< Microwave-assisted synthesis and biological activity of 2,5-disubstituted-1,3,4-thiadiazole>, SDS of cas: 70057-67-9, the main research area is carboxylic acid thiosemicarbazide cyclocondensation phosphoryl chloride dehydrating agent; thiadiazole preparation antifungal activity.
The reaction of substitute aryl and alkyl acid with thiosemicarbazide in the presence of dehydrating agent POCl3, affords a series of 2-amino-5-aryl-1,3,4-thiadiazoles under microwave irradiation 2,5-Disubstituted-1,3,4-thiadiazoles have attracted much attention due to their diverse biol. activities, such as antimicrobial, antibacterial, anesthetic, anticonvulsant and antiinflammatory activities. Compared with classical methods, this method has the advantages of high yields, short reaction time, easy preparation and mild reaction conditions. The preliminary biol. test showed that the synthesized compound has weak antifungal activity to G. zeae Petch, B. cinerea Pers, Phytophthora infestans (Mont.) de Bary, Botryosphaeria berengeriana f. sp. piricola (Nose) koganezawa et Sakuma, Fusarium oxysporum f.sp. cucumerinum and Cercospora arachidicola. The structures of compounds were characterized by m.ps., 1H NMR and IR.
Asian Journal of Chemistry published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, SDS of cas: 70057-67-9.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics