Zhang, Hongwang; Zhou, Longhu; Amichai, Sarah; Zandi, Keivan; Cox, Bryan; Schinazi, Raymond; Amblard, Franck published the artcile< Novel influenza polymerase PB2 inhibitors for the treatment of influenza A infection>, Reference of 2382-10-7, the main research area is pimodivir derivative preparation influenza A infection polymerase PB2 inhibitor; Antiviral; Flu; Influenza A; Virus.
Exploration of the chem. space of known influenza polymerase PB2 inhibitor Pimodivir, was performed by our group. We synthesized and identified compounds I and II, two novel thienopyrimidine derivatives displaying anti-influenza A activity in the single digit nanomolar range in cell culture. Binding of these unique compounds in the influenza polymerase PB2 pocket was also determined using mol. modeling.
Bioorganic & Medicinal Chemistry Letters published new progress about Antiviral agents (anti-influenza A). 2382-10-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H4Cl2N4, Reference of 2382-10-7.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics