Zhang, Pengfei; Guan, Aiying; Xia, Xiaoli; Sun, Xufeng; Wei, Siyuan; Yang, Jinlong; Wang, Junfeng; Li, Zhinian; Lan, Jie; Liu, Changling published the artcile< Design, Synthesis, and Structure-Activity Relationship of New Arylpyrazole Pyrimidine Ether Derivatives as Fungicides>, Computed Properties of 35852-58-5, the main research area is pyrimidine ether preparation fungicidal activity structure activity relationship; fungicidal activities; intermediate derivatization method (IDM); pyrimidine ether derivatives; structure−activity relationship.
To explore a novel fungicide effectively against cucumber downy mildew (CDM), a series of new arylpyrazole containing pyrimidine ether derivatives were designed and synthesized by employing the intermediate derivatization method (IDM). The structures of synthesized compounds were identified by 1H NMR, 13C NMR, elemental analyses, MS, and X-ray diffraction. Bioassays demonstrated that some of the title compounds exhibited excellent fungicidal activities against CDM. Especially, compound I (EC50 = 1.22 mg/L) displayed significantly higher bioactivity than that of com. fungicides diflumetorim and flumorph and nearly equal effect to that of cyazofamid. The relationship between the structure and fungicidal activity of the synthesized compounds was discussed as well. The study showed that compound I was a promising fungicide candidate for further development.
Journal of Agricultural and Food Chemistry published new progress about Fungicides. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Computed Properties of 35852-58-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics