Zheng, Bing; Li, Minyan; Gao, Gui; He, Yuying; Walsh, Patrick J. published the artcile< Palladium-Catalyzed α-Arylation of Methyl Sulfonamides with Aryl Chlorides>, Quality Control of 1435-43-4, the main research area is aryl sulfonamide preparation; methyl sulfonamide aryl chloride palladium catalyst monoarylation; Palladium-catalyzed; aryl chloride; arylation; sulfonamide; sumatriptan.
A palladium-catalyzed α-arylation of sulfonamides with aryl chlorides was presented. A Buchwald-type pre-catalyst formed with Kwong’s indole-based ligand enabled this transformation to be compatible with a large variety of Me sulfonamides and aryl chlorides in good to excellent yields. Importantly, under the optimized reaction conditions, only monoarylated products were observed This method was applied to the efficient synthesis of sumatriptan, which wass used to treat migraines.
Advanced Synthesis & Catalysis published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Quality Control of 1435-43-4.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics