Zhou, Jie; Zhang, Yi; Cui, Yi-Wen; Li, Zhan-Mei; Song, Hong-Rui; Dong, Jin-Hua; Chen, Xiao-Guang; Xu, Bai-Ling published the artcile< Synthesis and cytotoxic evaluation of N-(4-methoxy-1H-benzimidazol-7-yl)arenesulfonamide and N-aryl-(4-methoxy-1H-benzimidazol)-7-sulfonamide analogs of combretastatin A-4>, Computed Properties of 42413-03-6, the main research area is antitumor anticancer agent combretastatin analog preparation.
Benzimidazole derivatives [Combretastatin A-4 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol analogs] were designed and the synthesis of the target compounds was achieved using 4-methoxy-1H-benzimidazol-7-amine and 4-Methoxy-1H-benzimidazole-7-sulfonic acid as reactants. The title compounds were evaluated in-vitro against cell line HCT-8 (human epithelial intestinal adenocarcinoma, colon carcinoma), cell line BEL-7402 (hepatocellular carcinoma, human hepatoma, liver cancer cell line), cell line BGC 823 (human gastric cancer cell line, stomach adenocarcinoma), cell line A549 (human lung carcinoma cell line) and cell line A-2780 (human ovarian carcinoma cell line) and it was discovered that several compounds displayed cytotoxic activity against the HCT-8 cell line.
Journal of Asian Natural Products Research published new progress about Adenocarcinoma (epithelial adenocarcinoma, intestine). 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Computed Properties of 42413-03-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics