Afanasyev, Oleg I.; Kliuev, Fedor S.; Tsygankov, Alexey A.; Nelyubina, Yulia V.; Gutsul, Evgenii; Novikov, Valentin V.; Chusov, Denis published the artcile< Fluoride Additive as a Simple Tool to Qualitatively Improve Performance of Nickel-Catalyzed Asymmetric Michael Addition of Malonates to Nitroolefins>, COA of Formula: C8H6ClNO2, the main research area is nitroalkene dialkyl malonate nickel catalyst enantioselective Michael addition; dialkylnitroethylmalonate preparation.
Described that simple in-situ addition of the fluoride source to the asym. organometallic catalyst was improved not only activity but also enantioselectivity. Bromide-nickel diimine complexes were found to catalyze asym. Michael addition in low yields and ee, but activation with fluoride leads to a significant improvement in catalyst performance. The developed approach were applied to prepare several enantioenriched GABA analogs.
Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, COA of Formula: C8H6ClNO2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics