Baliah, V.; Balasubramanian, Theymoli Mrs. published an article in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry. The title of the article was 《Steric enhancement of resonance: Part I. Dissociation constants of some mono-, di- and tri-substituted benzoic acids》.Reference of 3,5-Dichloro-4-methoxybenzoic acid The author mentioned the following in the article:
The dissociation constants of 20 benzoic acids were determined in 50 volume % EtOH-H2O using the conductometric method. The calculated acidity constants of 3,4-R(MeO)C6H3CO2H (R = halo, Me) are appreciably higher than exptl. determined acidity constants which indicates that the 3-substituent enhances the resonance interaction between the MeO and CO2H groups. The expected steric inhibition of resonance is observed in 3,5,4-R2(MeO)C6H2CO2H. The acidity constants were also analyzed in terms of their free energies of ionization. The experimental part of the paper was very detailed, including the reaction process of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Reference of 3,5-Dichloro-4-methoxybenzoic acid)
3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 3,5-Dichloro-4-methoxybenzoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics