HPLC of Formula: 150444-93-2On May 21, 1995 ,《Directed lithiation of unprotected benzoic acids》 appeared in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry. The author of the article were Bennetau, Bernard; Mortier, Jacques; Moyroud, Joeel; Guesnet, Jean-Luc. The article conveys some information:
Benzoic acid gives the ortho-lithiated species (2-carboxyphenyl)lithium (lithium salt) under standard conditions. Reaction of (2-carboxyphenyl)lithium (lithium salt) at -78 °C with either Me iodide, di-Me disulfide, hexachloroethane, or 1,2-dibromotetrachloroethane gives the ortho-substituted product. Intramol. competition between the carboxylic acid and methoxy, chloro, fluoro, or diethylamino functions in ortho- and para-substituted benzoic acids establishes the carboxylic acid group to be of intermediate capacity in directing metalation. Complimentarity of directing effects is observed with the chloro and fluoro groups in the meta-substituted benzoic acids but not with the methoxy and trifluoromethyl groups. Electrophile introduction into meta- and para-lithiated benzoates occurs with equal efficacy and comparable scope. The 2,4-dihalobenzoic acids undergo hydrogen/metal exchange at the position flanked by both halogen substituents. 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid undergoes lithiation adjacent to the oxygen atom. By use of such methods, routes to benzoic acids contiguously tri- and tetra-substituted with a variety of functionalities have been developed. The experimental part of the paper was very detailed, including the reaction process of 2-Chloro-3,4-difluorobenzoic acid(cas: 150444-93-2HPLC of Formula: 150444-93-2)
2-Chloro-3,4-difluorobenzoic acid(cas: 150444-93-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. HPLC of Formula: 150444-93-2 Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics