Donnelly, Kian; Baumann, Marcus published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《A continuous flow synthesis of [1.1.1]propellane and bicyclo[1.1.1]pentane derivatives》.Synthetic Route of C3H3ClO3 The article contains the following contents:
A continuous flow process to generate [1.1.1]propellane on demand is presented rendering solutions of [1.1.1]propellane that can directly be derivatized into various bicyclo[1.1.1]pentane (BCP) species I [R = H, I, phenylsulfanyl, (butan-2-yloxy)carbonyl, etc.; R1 = I, (4-tert-butylphenyl)sulfanyl, N-(4-fluorophenyl)carbamoyl, etc.]. This was realized in throughputs up to 8.5 mmol h-1 providing an attractive and straightforward access to gram quantities of selected BCP building block I (R = R1 = I). Lastly, a continuous photochem. transformation of [1.1.1]propellane into valuable BCPs bearing mixed ester/acyl chloride moieties II (R2 = Me, Et, i-Pr, dodecyl, butan-2-yl) was developed. In the experimental materials used by the author, we found Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Synthetic Route of C3H3ClO3)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Synthetic Route of C3H3ClO3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics