《A cascade approach to 3D cyclic carbamates via an ionic decarboxylative functionalization of olefinic oxamic acids》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Fan, Huaqiang; Wan, Yi; Pan, Peng; Cai, Wenbin; Liu, Shihui; Liu, Chuanxu; Zhang, Yongqiang. Synthetic Route of C3H3ClO3 The article mentions the following:
An m-CPBA-mediated intramol. epoxidation-decarboxylative alkoxylation cascade reaction of olefinic oxamic acids, e.g., 2-oxo-2-((2-(prop-1-en-2-yl)phenyl)amino)acetic acid has been developed. The distinct ionic decarboxylative mechanism was preliminarily revealed. The protocol features mild reaction conditions and operational simplicity, allowing the construction of diverse medicinally valuable 5-7 membered 3D cyclic carbamate architectures e.g., 4-(hydroxymethyl)-4-methyl-1H-benzo[d][1,3]oxazin-2(4H)-one in moderate to high yields. In the experimental materials used by the author, we found Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Synthetic Route of C3H3ClO3)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Synthetic Route of C3H3ClO3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics