Galley, Guido; Beurier, Angelica; Decoret, Guillaume; Goergler, Annick; Hutter, Roman; Mohr, Susanne; Pahler, Axel; Schmid, Philipp; Turck, Dietrich; Unger, Robert; Zbinden, Katrin Groebke; Hoener, Marius C.; Norcross, Roger D. published the artcile< Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists>, Application of C8H8BrCl, the main research area is aminooxazoline TAAR agonist; 2-aminooxazoline; SAR; TAAR1 agonist; schizophrenia.
2-Aminooxazolines were discovered as a novel structural class of TAAR1 ligands. Starting from a known adrenergic compound, structural modifications were made to obtain highly potent and selective TAAR1 ligands such as (I) (RO5166017), (II) (RO5256390), RO5203648, and RO5263397. These compounds exhibit drug-like physicochem. properties, have good oral bioavailability, and display in vivo activity in a variety of animal models relevant for psychiatric diseases and addiction.
ACS Medicinal Chemistry Letters published new progress about Antipsychotics. 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Application of C8H8BrCl.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics