Guan, Peng; Wang, Lei; Hou, Xuben; Wan, Yichao; Xu, Wenfang; Tang, Weiping; Fang, Hao published the artcile< Improved antiproliferative activity of 1,3,4-thiadiazole-containing histone deacetylase (HDAC) inhibitors by introduction of the heteroaromatic surface recognition motif>, Quality Control of 70057-67-9, the main research area is antiproliferative thiadiazole preparation histone deacetylase inhibitor structure activity modeling; 1,3,4-Thiadiazole; Antiproliferation; Histone deacetylase inhibitor; Hydroxamic acid; Surface recognition motif.
A series of 1,3,4-thiadiazole-containing hydroxamic acids, in accord with the common pharmacophore of histone deacetylase (HDAC) inhibitors (a Zn2+ binding moiety-a linker-a surface recognition motif), was identified as submicromolar HDAC inhibitors by the authors’ group. In this study, the authors continued the efforts to develop 1,3,4-thiadiazole bearing hydroxamate analogs by modifying the surface recognition motif. The authors found that 1,3,4-thiadiazoles having a heteroaromatic substituent showed better HDAC inhibitory activity in enzymic assay and higher antiproliferative potency in cellular assay compared to SAHA.
Bioorganic & Medicinal Chemistry published new progress about Antiproliferative agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Quality Control of 70057-67-9.
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