《Field-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agent》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Hwang, Soo-Yeon; Park, Soo-Yeon; Hong, Jung Yeon; Lee, Soo Yeon; Shin, Jae-Ho; Na, Younghwa; Sohn, Myung Hyun; Yoon, Ho-Geun; Kwon, Youngjoo. Safety of 3-Chlorobenzylchloride The article mentions the following:
(E)-3-(3-(4-((3-Carbamoylbenzyl)oxy)-3-iodo-5-methoxyphenyl) acryloyl)benzamide (A6) was found to be a potent p300 inhibitor (IC50 = 870 nM) showing a similar binding mode to that of acetyl-CoA, a p300 substrate, and effective anti-fibrotic activity in both TGF-β1-stimulated lung fibroblast cells and bleomycin-induced in vivo lung fibrosis mice. In the experiment, the researchers used 3-Chlorobenzylchloride(cas: 620-20-2Safety of 3-Chlorobenzylchloride)
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Safety of 3-Chlorobenzylchloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics