《Synthesis and enzyme-based evaluation of analogues L-tyrosine thiol carboxylic acid inhibitor of metallo-β-lactamase IMP-1》 was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2019. These research results belong to Khalili Arjomandi, Omid; Kavoosi, Mahboubeh; Adibi, Hadi. Related Products of 620-20-2 The article mentions the following:
The emergence of drug-resistant pathogenic bacteria is occurring due to the global overuse and misuse of β-lactam antibiotics. Infections caused by some bacteria which secrete metallo-β-lactamases (enzymes that inactivate β-lactam antibiotics) are increasingly prevalent and have become a major worldwide threat to human health. These bacteria are resistant to β-lactam antibiotics and MBL-inhibitor/β-lactam antibiotic combination therapy can be a strategy to overcome this problem. So far, no clin. available inhibitors of metallo-β-lactamases (MBLs) have been reported. In this study, L-benzyl tyrosine thiol carboxylic acid analogs (I) were synthesized after the study of computational simulation by adding of Me, chloro, bromo, and nitro groups to the benzyl ring for investigation of SAR anal. Although the synthesized mols. shows the potent inhibitory effects against metallo-β-lactamase (IMP-1) with the range of Kic values of 1.044.77 μM, they are not as potent as the candidate inhibitor.3-Chlorobenzylchloride(cas: 620-20-2Related Products of 620-20-2) was used in this study.
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Related Products of 620-20-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics