Liu, Zheng; Bian, Ming; Ma, Qian-Qian; Zhang, Zhuo; Du, Huan-Huan; Wei, Cheng-Xi published the artcile< Design and synthesis of new benzo[d]oxazole-based derivatives and their neuroprotective effects on β-amyloid-induced PC12 cells>, HPLC of Formula: 70057-67-9, the main research area is benzoxazolylthio aryl thiadiazolyl acetamide preparation Alzheimer neuroprotective amyloid; Akt/GSK-3β/NF-κB signaling pathway; Alzheimer’s disease; benzo[d]oxazol; synthesis; thiadiazoles; β-amyloid.
A series of novel synthetic substituted benzo[d]oxazole-based derivatives I (R = H, 3,4,5-(OMe)3, 2-Cl-5-F, etc.) exerted neuroprotective effects on β-amyloid (Aβ)-induced PC12 cells as a potential approach for the treatment of Alzheimer’s disease (AD). In vitro studies show that most of the synthesized compounds I were potent in reducing the neurotoxicity of Aβ25-35-induced PC12 cells at 5μg/mL. The compound I (R = 3-Cl) (II) was non-neurotoxic at 30μg/mL and significantly increased the viability of Aβ25-35-induced PC12 cells at 1.25, 2.5 and 5μg/mL. Western blot anal. showed that compound II promoted the phosphorylation of Akt and glycogen synthase kinase (GSK-3β) and decreased the expression of nuclear factor-κB (NF-κB) in Aβ25-35-induced PC12 cells. In addition, the findings demonstrated that compound II protected PC12 cells from Aβ25-35-induced apoptosis, reduced the hyperphosphorylation of tau protein, and decreased the expression of receptor for AGE (RAGE), β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1), inducible nitric oxide synthase (iNOS) and Bcl-2-associated X protein/B-cell lymphoma 2 (Bax/Bcl-2) via Akt/GSK-3β/NF-κB signaling pathway. In vivo studies suggest that compound II shows less toxicity than donepezil in the heart and nervous system of zebrafish.
Molecules published new progress about Alzheimer disease. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, HPLC of Formula: 70057-67-9.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics