Morris, Joel; Wishka, Donn G.; Fang, Yue published the artcile< A cyclodehydration route to 2-aminochromones>, Safety of Methyl 4-chloro-2-hydroxybenzoate, the main research area is salicylacetamide preparation cyclodehydration; cyclocondensation salicylacetamide; aminochromone; salicylate reaction amide enolate.
Cyclodehydration of salicylacetamides I with triflic anhydride efficiently provided the corresponding 2-aminochromone II (R1 = H, 6-, 7-, 8-MeO, 6-Br, 7-Cl, 7-, 8-Me; NR2 = NMe2, 4-morpholino) in 59-79% yield. The use of polyphosphoric ester (PPE) for this process was somewhat less effective. However, the deacylated derivative of compound II (R1 = AcNH, NR2 = 4-morpholino) was prepared in only 10% yield with triflic anhydride as reagent, whereas PPE as reagent afforded the expected compound II in 44% yield. Compounds I were prepared by reaction of substituted Me salicylates with an amide enolate.
Synthetic Communications published new progress about Cyclocondensation reaction. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Safety of Methyl 4-chloro-2-hydroxybenzoate.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics