《Synthesis, characterization and biological evaluation of novel series of [2-(benzylamino)-2-oxoethyl]-2-oxo-2H-1-benzopyran-3-carboxamide derivatives》 was published in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry in 2020. These research results belong to Naik, Mamata Devendra; Bodke, Yadav D.; Ajeesh Kumar, A. K.; Naik, Jayanth K.; Shastri, Sudhesh L.. COA of Formula: C7H7ClFN The article mentions the following:
A novel series of benzopyran-3-carboxamide derivatives I (R = Ph, 2-chlorophenyl, 4-methoxyphenyl, 2-chloro-3-fluorophenyl, etc.) have been designed and synthesized using a smooth and linear multistep synthesis. Amidation of coumarin-3-carboxylic acid with glycine Et ester in the presence of EDC.HCl and HOBt as coupling agent followed by the hydrolysis results in the formation of key synthon, [(2-oxo-2H-1-benzopyran-3-carbonyl) amino] acetic acid which is further coupled with substituted aryl amines RCH2NH2 using HATU in combination with Hunig’s base to get the target compounds I. The synthesized compounds I have been screened for their in vitro antibacterial and antioxidant activity and the results are expressed as MIC and IC 50 values resp. Further, the binding ability of synthesized compounds I with different proteins have been examined by mol. docking studies. In the experiment, the researchers used many compounds, for example, (2-Chloro-3-fluorophenyl)methanamine(cas: 72235-54-2COA of Formula: C7H7ClFN)
(2-Chloro-3-fluorophenyl)methanamine(cas: 72235-54-2) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.COA of Formula: C7H7ClFN
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics