The author of 《Discovery and evaluation of novel synthetic 5-alkyl-4-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoxaline-1-carbox-amide derivatives as anti-inflammatory agents》 were Shen, Qing-Kun; Gong, Guo-Hua; Li, Gao; Jin, Mei; Cao, Li-Hua; Quan, Zhe-Shan. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. Name: 3-Chlorobenzylchloride The author mentioned the following in the article:
To develop novel anti-inflammatory agents, a series of 5-alkyl-4-oxo-4,5-dihydro-[1, 2, 4]triazolo[4,3-a]quinoxaline-1-carboxamide derivatives were designed, synthesized, and evaluated for anti-inflammatory effects using RAW264.7 cells. Structures of the synthesized compounds were determined using 1H NMR, 13 C NMR, and HRMS. All the compounds were screened for anti-inflammatory activity based on their inhibitory effects against LPS-induced NO release. Among them, 5-(3,4,5-trimethoxybenzyl)-4-oxo-4,5-dihydro-[1, 2, 4]triazolo[4,3-a]quinoxaline-1-carboxamide () showed the highest anti-inflammatory activity and inhibited NO release more potently than the lead compound . Further studies revealed that compound reduced the levels of NO, TNF-α, and IL-6, and that its anti-inflammatory activity involves the inhibition of COX-2 and iNOS and downregulation of the mitogen-activated protein kinases (MAPK) signal pathway. Notably, compound displayed more prominent anti-inflammatory activity than and the pos. control ibuprofen in the in vivo acute inflammatory model. Overall, these findings indicate that compound is a therapeutic candidate for the treatment of inflammation. The experimental part of the paper was very detailed, including the reaction process of 3-Chlorobenzylchloride(cas: 620-20-2Name: 3-Chlorobenzylchloride)
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Name: 3-Chlorobenzylchloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics