Tang, Yan-Ling; Zheng, Xi; Qi, Yan; Pu, Xiao-Jia; Liu, Bei; Zhang, Xia; Li, Xiao-Si; Xiao, Wei-Lie; Wan, Chun-Ping; Mao, Ze-Wei published the artcile< Synthesis and anti-inflammatory evaluation of new chalcone derivatives bearing bispiperazine linker as IL-1β inhibitors>, Application In Synthesis of 17082-09-6, the main research area is bispiperazinochalcone preparation antitumor antiinflammatory activity interleukin inhibitor; Anti-inflammatory activity; Chalcone derivatives; Cytotoxicity; IL-1β inhibitors.
In this work, a series of novel chalcone derivatives I (n = 1,2; R = H, 3-chloropropanoyl, (3,5-dichlorophenyl)carbonyl, (4-nitrophenyl)methyl, etc.) bearing bispiperazine linker have been synthesized and in vitro anti-inflammatory, cytotoxic activity and anti-inflammatory mechanism have been screened. The results indicated that most bispiperazinochalcone derivatives I displayed good inhibition of NO (IC50 < 20μM) and low cytotoxicity (CC50 > 40μM), and selectively inhibited the production of IL-1β via inhibiting NLRP3 inflammasome activation, as promising candidate compounds for the treatment of NLRP3 inflammasome-driven diseases.
Bioorganic Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics