In 2019,Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry included an article by Taywade, Amol; Berad, Baliram. Safety of 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《Hunig’s base a facile and green alternative for C-N bond formation reactions》. The information in the text is summarized as follows:
A new dimension to Hunig’s base i.e. diisopropylethylamine (DIPEA) utilization in the organic reaction were studied. Present study projects DIPEA as a green alternative for C-N bond formation reactions. In terms of optimization of yield of C-N coupling reactions, DIPEA exclusively serves as base, catalyst and solvent in mild conditions to fulfill criteria for green reaction methodol. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Safety of 1-(Bromomethyl)-4-chlorobenzene)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Safety of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics