Vishe, Mahesh; Johnston, Jeffrey N. published the artcile< The inverted ketene synthon: a double umpolung approach to enantioselective β2,3-amino amide synthesis>, Name: (E)-1-Chloro-4-(2-nitrovinyl)benzene, the main research area is amino amide synthesis enantioselective diastereoselective; oxime preparation reduction; dinitro alkane preparation amine umpolung; ethane nitro styrene Michael addition enantioselective.
A stereocontrolled synthesis of β2,3-amino amides I [R = Me, Ph, 4-MeC6H4; R1 = Ph, 4-MeOC6H4; R2 = Ac, Cbz, Fmoc] was reported. Innovation was encapsulated by the first use of nitroalkenes to achieve double umpolung in enantioselective β2,3-amino amide synthesis. Step economy was also fulfilled by the use of umpolung Amide Synthesis (UmAS) in the second step, delivering the amide product without intermediacy of a carboxylic acid or activated derivative Molybdenum oxide-mediated hydride reduction provided the anti-β2,3-amino amides I with high selectivity.
Chemical Science published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Name: (E)-1-Chloro-4-(2-nitrovinyl)benzene.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics