Xu, Jun; Yang, Tianjiao; Wang, Jiayi; Song, Gonghua published an article on January 31 ,2021. The article was titled 《Multistep Synthesis and Nematicidal Activity of 2-(8-azabicyclo[3.2.1]octan-3-yl)-3-imino-2,3-dihydro-1H-isoindol-1-One Derivatives》, and you may find the article in Chemistry of Heterocyclic Compounds (New York, NY, United States).Safety of 3-Chlorobenzylchloride The information in the text is summarized as follows:
Novel 2-(8-azabicyclo[3.2.1]octan-3-yl)-3-imino-2,3-dihydro-1H-isoindol-1-ones I [R = H, 5-F, 6-MeO, 5-Cl; R1 = Me, benzyl, 4-chlorobenzyl, etc.; R2 = tert-Bu, cyclohexyl, 2-MeOC6H4, etc.] which derived from 5-HT3 receptor antagonists hexahydroazepinylbenzamides were designed and synthesized through isocyanide insertion reaction. All target compounds I were evaluated against pinewood nematodes B. xylophilus and root-knot nematodes M. incognita. Good lethal rate (75%) for I [R = 5-Cl, R1= Me, R2 = tert-butyl] and serious nervous curl effect against pinewood nematodes B. xylophilus for I [R = H, R1= Me, R2 = tert-butyl] were observed at 10 mg/l. The inhibition activities of I [R = H, R1= Me, R2 = 2-MeOC6H4, etc.] against root-knot nematodes M. incognita were 84% at 160 mg/l and 60% at 20 mg/l for in-vitro test and test tube test, resp. In the experiment, the researchers used many compounds, for example, 3-Chlorobenzylchloride(cas: 620-20-2Safety of 3-Chlorobenzylchloride)
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Safety of 3-Chlorobenzylchloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics