Zhuang, Xiaohui; Shi, Xiayue; Zhu, Rui; Sun, Bin; Su, WeiKe; Jin, Can published the artcile< Photocatalytic intramolecular radical cyclization involved synergistic SET and HAT: synthesis of 3,3-difluoro-γ-lactams>, Synthetic Route of 29027-20-1, the main research area is difluoro lactam preparation regioselective; allyl propargyl bromo difluoro arylacetamide photocatalytic intramol radical cyclization.
A mild and metal-free protocol for visible-light induced intramol. radical cyclization of N-allyl(propargyl)-2-bromo-2,2-difluoro-N-arylacetamide was developed. This strategy showed excellent regioselectivity and simple operation to synthesize 4-substituted 3,3-difluoro-γ-lactams I [R1 = Ph, 4-FC6H4, 3,5-di-MeC6H3, etc.; R2 = H, Me; R3 = H, Me, CO2Me, etc.; R4 = H, 4-MeOC6H4; X = (CHR4)n; n = 1, 2] and II [R4 = H, Me, Et] with a broad substrate scope. Moreover, mechanistic studies revealed that this transformation proceeded through a cascade radical-type cyclization and hydrogen atom transfer process with PMDETA as a hydrogen-atom donor.
Organic Chemistry Frontiers published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (allyl). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Synthetic Route of 29027-20-1.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics